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Iroquois, TGIF) reveals a novel domain conserved between plants and animals . [PubMed] [CrossRef] [Google Scholar]; Gordon J.A.R., Hassan M.Q., Saini S., Lupus. ;– doi: / [PubMed]. Systemic lupus erythematosus (SLE) is a heterogeneous, inflammatory . This affects various daily activities including opening jars and moving. Download This eBook. Tips: Just input part of file name. Example: To search Lupus Cewek Junkies Just input keyword Cewek Junkies or Lupus. Loading.
Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. Pbx1 represses osteoblastogenesis by blocking Hoxamediated recruitment of chromatin remodeling factors.
Mol Cell Biol. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
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Lupus and T cells. Nat Rev Rheumatol.
DOI: Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Functional dissection of systemic lupus erythematosus using congenic mouse strains. Polygenic control of susceptibility to murine systemic lupus erythematosus.
Curr Opin Immunol. Murine models of systemic lupus erythematosus. J Biomed Biotechnol. Pre-B cell leukemia transcription factor PBX proteins are important mediators for retinoic acid-dependent endodermal and neuronal differentiation of mouse embryonal carcinoma P19 cells.
J Biol Chem. Pbx3 deficiency results in central hypoventilation. Am J Pathol. Curr Top Microbiol Immunol. However, as it has been a number of years since that review, there is value in a more up to date review of the literature which identifies relevant concepts for measurement and the adequacy of existing measures to assess those concepts. In particular, no disease-specific measures of health status or disability were identified at that time.
The objectives of this research were twofold. This included an overview of the economic burden of SLE. Based on development of the conceptual model, the objective was then to review existing PRO measures for suitability in clinical trials of SLE, in terms of their content validity, face validity and psychometric properties.
Methods A structured literature review was conducted to establish the humanistic and economic burden with respect to the key symptoms and their impact, and the PROs available to measure these.
Methods were in line with recognised international guidelines for the conduct and reporting of literature reviews [ 18 ],[ 19 ].
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The search was conducted on 1st August Articles with an SLE-related clinical search term and at least one of the humanistic or economic search terms were selected. Search terms included SLE clinical terms systemic lupus erythematosus, SLE, lupus nephritis, LN plus outcomes research terms health-related quality of life, quality of life, patient burden, patient impact, burden of illness, symptom, activities of daily living, patient reported outcome, patient related outcome, PRO, questionnaire, fatigue, physical function, emotion, mood or economic terms cost OR cost utility, cost of illness, healthcare cost, economic burden, economic impact, resource use, hospitalisation, productivity, expenditure, direct costs, indirect costs, economic, cost minimisation, burden of illness, cost effectiveness.
Screening process and data extraction Two researchers screened and checked all the abstracts for eligibility and suitability in line with the Centre for Reviews and Dissemination guidance [ 19 ].
Articles selected for review were based on consensus opinion. Any disagreement in the selection of articles was resolved by the lead researcher who performed a final, independent review of titles and abstracts. The selected articles were categorised into qualitative studies reporting burden from the patient perspective and articles reporting humanistic and economic burden data. Study characteristics from the selected articles were extracted.
Development of the conceptual model of systemic lupus erythematosus A conceptual model of the humanistic and economic burden of SLE was developed on the basis of the review of qualitative studies [ 20 ]. A conceptual model can help identify themes, describe the patient burden concepts and their interrelationships and provide the rationale for PRO measures of interest [ 11 ],[ 21 ].
For the purposes of this study, a conceptual model for SLE provided the theoretical basis for the review and evaluation of the content validity of the selected PRO measures.
The model was then compared with an existing SLE conceptual model developed by Gallop et al. Review of the patient-reported outcome measures for systemic lupus erythematosus A subset of the PRO measures identified in the literature search were selected for in-depth review.
Selection of instruments for in-depth review was based on likelihood of meeting the FDA guidance and relevance of conceptual coverage, based on review of the abstract and initial review of the PRO. Articles in the literature search that reported PRO data were categorised according to the type of PRO measure included in each study. The categories were largely based on the key concepts identified in the conceptual model.
Each PRO was reviewed for appropriateness for clinical trials in patients with SLE in terms of content validity, face validity and psychometric properties, in line with regulatory guidance for the evaluation of PRO measures [ 11 ],[ 12 ]. Content validity was assessed by the coverage level of the concepts within the conceptual model [ 11 ],[ 12 ]. The face validity of each PRO measure was determined by the acceptability and appropriateness of item wording, recall period and response options to patients with SLE.Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus.
However, as it has been a number of years since that review, there is value in a more up to date review of the literature which identifies relevant concepts for measurement and the adequacy of existing measures to assess those concepts.
Partial [ 89 ]. SHARE this giveaway on Facebook with this link , or use the social media icons at the bottom of the post.
Methods were in line with recognised international guidelines for the conduct and reporting of literature reviews [ 18 ],[ 19 ]. J Immunol. Application of the multidimensional fatigue inventory MFI in cancer patients receiving radiotherapy.
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The prevalence of SLE is greater in non-white racial groups [ 2 ] and the disease affects women more frequently than men [ 4 ].